ibrutinib Product Description
Product Name: Ibrutinib (PCI-32765)
CAS No.: 936563-96-1
Information: Bruton's tyrosine kinase (BTK) inhibitor
Description: Ibrutinib is a potent and highly selective inhibitor of Btk with IC50 of 0.5 nM, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.
Other Names: PCI-32765,Ibrutinib,CRA-032765
Chemical Name: 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
Canonical SMILES: C=CC(=O)N1CCCC(C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N
Purity: 99% min,
Appearance: White powder
Type: Antineoplastic Agents
Grade Standard: Medicine Grade
Solubility: Soluble in DMSO > 10 mM
Storage: Desiccate at -20°C
General tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition: Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
Background: Ibrutinib (PCI-32765), also named as Ibrutinib, is a Bruton tyrosine kinase inhibitor which is used to study the biological effects of Bruton tyrosine kinase inhibition on mature B-cell function and the progression of B cell-associated diseases in vivo. The Bruton tyrosine kinase is specifically necessary for BCR signaling as demonstrated by human and mouse mutations that disrupt Bruton tyrosine kinase function and prevent B-cell maturation at steps which need a functional BCR pathway. PCI-32765 also inhibited autoantibody production. Occupancy of the Bruton tyrosine kinase active site by PCI-32765 was monitored in vitro and in vivo using a fluorescent affinity probe for Bruton tyrosine kinase.
Usage: Antineoplastic Agents
Inventory status: in stock
HPLC Spectrum: Available
NMR (Nuclear Magnetic Resonance): Available
Packaging Details:1g,5g,10g,50g,100g/bottle, 1kg/tin for trial order,25kg/drum for commercial